Endocrine Abstracts

Background: Non-islet-cell tumour hypoglycaemia (NICTH) is a rare paraneoplastic syndrome caused by an extra pancreatic tumour(1). Solitary fibrous tumour (SFT), amongst other tumours, is one of the rare causes of NICTH. We report a case of NICTH who presented with recurrent hypoglycaemias and was identified to have a fibrous tumour as part of the work up for his symptomatic hypoglycaemias.Case Summary: A 75-year male had presented to the emergency depar...

Introduction: Thyroid dysfunction in pregnancy is not uncommon (1). Early recognition and intervention are essential to avoid any adverse pregnancy outcomes however caution must be exercised while interpreting the thyroid functions during pregnancy to avoid any unnecessary treatment.Case report: 32-year female with was referred to the combined antenatal clinic for review following an abnormal thyroid function tests during pregnancy. She had no known medi...

Background: Bruns Garlands syndrome is a rare disorder in people living with diabetes, manifesting as unilateral or bilateral muscle pain, weakness and atrophy in the proximal region of the lower limbs. Herein, we present the case of a patient with Bruns-Garland syndrome caused by sodium/glucose co-transporter 2 inhibitors (SGLT2i).Case description: A 55-year-old male with background of type 2 diabetes for 5 years, and currently on oral therapy, presente...

A 51-year-old lady presented as an emergency with disabling, recurrent hypercalcaemia in July and August, 2015 with a peak corrected calcium of 3.94 mmol/l (normal range 2.2–2.6). She had been diagnosed with a stage 1A endometrial cancer, treated with hysterectomy and bilateral salpingo-oophorectomy in April 2014. Significant pelvic and left groin lymphadenopathy was noted, and was found to be enlarging on surveillance CT of July 2015. She was also found to have a left ki...

A 51-year-old man presented to an optometrist with a 3-week history of visual impairment following a minor headache. He was found to have reduced visual acuity 6/24 in both eyes and a dense bitemporal hemianopia and was referred urgently to Musgrove Park Emergency Department. MRI brain showed a cystic bleed from a pituitary macroadenoma, 30 mm in diameter, with compression of the optic chiasm. He had no clinical features of Cushing’s or other hormone excess or deficiency ...

Membrane proteins of the endoplasmic reticulum (ER) are involved in a wide array of essential cellular functions. Identification of the topology of membrane proteins can provide important insight into their mechanisms of action and biological roles. This is particularly important for membrane enzymes, since their topology determines the subcellular site where a biochemical reaction takes place and the dependence on luminal or cytosolic substrates and co-factor pools. The metho...

Introduction: Prevalence of so-called diabetes prone to ketosis (DPK), has been increasing. The necessity of lifelong insulinotherapy is determined by Aβ classification of DPK.Design: Seven patients with atypical course of T2DM were studied. All patients had gradual development of hyperglycemia, obesity 1–2 stages, and acetonuria. Noone had acute weight loss. Stage 3 had positive GAD-AB, stage 4 – negative. Initially all patients were trea...

Aim: Clinical guidelines recommend the cancellation of dopamine agonists after confirmation of pregnancy as because further their use is unnecessary. However, an implementation of these recommendations in real clinical practice is unknown which became the aim of our present research.Materials and methods: The study included 21 patients with prolactinomas who had 26 pregnancies ended in childbirth. These patients were found archived medical records of End...

The definitive treatment for Cushing’s disease is curative surgery. Patients with severe disease burden will likely require pre-operative medical blockade to reduce the risk of peri- and post-operative complications. The threshold for deciding when to medically block excess cortisol is currently based on clinical judgment. Expert centres may use a different criteria to determine this. There is no widely adopted tool for evaluating the clinical severity of Cushing’s d...

Introduction: Gigantomastia is a rare condition characterised by excessive benign breast tissue growth that is thought to be a result of elevated physiological levels of circulating hormones (e.g. pregnancy), or an increased sensitivity of the breast tissue to such hormones. Isolated reports describe some medical conditions as precipitants (e.g. systemic lupus erythematosus (SLE)) or drugs (e.g. cyclosporine). Many will proceed to surgical intervention to improve physical and/...